Evaluation of antioxidant, photoprotective and antinociceptive activities of Marcetia macrophylla extract: potential for formulation of sunscreens

Abstract The antioxidant, photoprotective and antinociceptive Marcetia macrophylla active extract was investigated as an ingredient in a sunscreen cream formulation. Thus, the M. showed IC50 of 3.43 mg/ml antioxidant (DPPH∙ scavenging test) Sun Protection Factor 20.25 (SPF/UV-B, at 250 µg/ml) UV-A 78.09% (photobleaching trans-resveratrol test). activity superior to all standards tested using vivo acetic acid-induced writhing test (99.14% dose 200 mg/kg) high-performance liquid chromatography coupled with diode array detector mass spectroscopy multi-stage (HPLC-DAD-MS/MS) enabled structural characterization quercetin-3-O-hexoside, quercetin-3-O-pentoside quercetin-3-O-desoxihexoside. pharmaceutical formulation containing crude prepared physicochemical tests (organoleptic characteristics, pH analysis centrifugation), vitro UVB (sun protection factor, SPF) UVA (β-carotene) spectroscopic method were investigated. satisfactory results concerning parameters evaluated against UV test. biological activities potential use preparations.